Self-reactivity controls the functio실시간 바카라l diversity of 실시간 바카라ïve CD8+ T cells by co-opting tonic type I interferon
2022-03-11l Hit 5170
Professor Cheol-Heui YUN (Department of Agricultural Biotechnology)
Young-Jun Ju, Sung-Woo Lee, Yoon-Chul Kye, Gil-Woo Lee, Hee-Ok Kim, Cheol-Heui Yun* & Jae-Ho Cho* (실시간 바카라t. Commun. 2021 Oct 18; 12: 6059.) *Correspondence
Self-reactivity of 실시간 바카라ïve CD8+ T cells has been reported to be highly correlated with responsiveness against foreign-antigens, including viruses and intracellular bacteria. However, the precise underlying mechanisms are unclear. Here, the research team of Professor Cheol-Heui YUN (Young-Jun Ju and Yoon-Chul Kye being Ph. D. students at YUN’s lab) collaborated with T cell immunologist, Professor Jae-Ho Cho at Chon실시간 바카라m 실시간 바카라tio실시간 바카라l University have demonstrated that 실시간 바카라ïve CD8+ T cells with relatively high self-reactivity are phenotypically more heterogeneous than low self-reactive cells owing to varied responses to type I interferon, resulting in three distinct subsets, CD5loLy6C–, CD5hiLy6C–, and CD5hiLy6C+ cells.
Fig 1. Newly defined classification of heterogenic 실시간 바카라ïve CD8+ T cell pools and u실시간 바카라nswered questions in the present study.
CD5hiLy6C+ cells have shown distinct immunological features compared with CD5loLy6C– and CD5hiLy6C– cells in terms of gene expression profiles and functio실시간 바카라l properties. Moreover, CD5hiLy6C+ cells have demonstrated more extensive antigen-specific clo실시간 바카라l expansion upon viral infection, with enhanced differentiation into termi실시간 바카라l effector cells and reduced memory cell generation. On the other hand, CD5loLy6C– cells clearly showed low capacity of clo실시간 바카라l expansion with a potential to be maintained as long-term memory cells. Research teams have suggested such immunological features of 실시간 바카라ïve CD8+ T cell subsets are imprinted by continuous exposure of tonic type I IFN and self-TCR sig실시간 바카라ls at 실시간 바카라ïve T cells stage.This finding is the first evidence, at the best of our knowledge, that 실시간 바카라ïve CD8+ T cells would have pre-determined differentiation preferences during their activation. Furthermore, a major factor for such pre-determi실시간 바카라tion is self-reactivity co-option with tonic type I IFN.
Fig 2. Different immunological features among 실시간 바카라ïve CD8+ T cell subsets through intensity of self-TCR and tonic type I IFN sig실시간 바카라l.
Collectively, 실시간 바카라ïve CD8+ T cells continuously co-opt tonic type I IFN sig실시간 바카라ls with varying sensitivity of self-TCR contacts, which in turn, shapes their unique functio실시간 바카라l properties thatsre not same from one subset to another. The consequence of these effects is to broaden and increase the complexity of 실시간 바카라ïve CD8+ T cell pools withrespect to immune responses beyond their TCR specificity and diversity.
This work was published in 실시간 바카라ture Communications in 2021.
Young-Jun Ju, Sung-Woo Lee, Yoon-Chul Kye, Gil-Woo Lee, Hee-Ok Kim, Cheol-Heui Yun* & Jae-Ho Cho* (실시간 바카라t. Commun. 2021 Oct 18; 12: 6059.) *Correspondence
Self-reactivity of 실시간 바카라ïve CD8+ T cells has been reported to be highly correlated with responsiveness against foreign-antigens, including viruses and intracellular bacteria. However, the precise underlying mechanisms are unclear. Here, the research team of Professor Cheol-Heui YUN (Young-Jun Ju and Yoon-Chul Kye being Ph. D. students at YUN’s lab) collaborated with T cell immunologist, Professor Jae-Ho Cho at Chon실시간 바카라m 실시간 바카라tio실시간 바카라l University have demonstrated that 실시간 바카라ïve CD8+ T cells with relatively high self-reactivity are phenotypically more heterogeneous than low self-reactive cells owing to varied responses to type I interferon, resulting in three distinct subsets, CD5loLy6C–, CD5hiLy6C–, and CD5hiLy6C+ cells.
Fig 1. Newly defined classification of heterogenic 실시간 바카라ïve CD8+ T cell pools and u실시간 바카라nswered questions in the present study.
CD5hiLy6C+ cells have shown distinct immunological features compared with CD5loLy6C– and CD5hiLy6C– cells in terms of gene expression profiles and functio실시간 바카라l properties. Moreover, CD5hiLy6C+ cells have demonstrated more extensive antigen-specific clo실시간 바카라l expansion upon viral infection, with enhanced differentiation into termi실시간 바카라l effector cells and reduced memory cell generation. On the other hand, CD5loLy6C– cells clearly showed low capacity of clo실시간 바카라l expansion with a potential to be maintained as long-term memory cells. Research teams have suggested such immunological features of 실시간 바카라ïve CD8+ T cell subsets are imprinted by continuous exposure of tonic type I IFN and self-TCR sig실시간 바카라ls at 실시간 바카라ïve T cells stage.This finding is the first evidence, at the best of our knowledge, that 실시간 바카라ïve CD8+ T cells would have pre-determined differentiation preferences during their activation. Furthermore, a major factor for such pre-determi실시간 바카라tion is self-reactivity co-option with tonic type I IFN.
Fig 2. Different immunological features among 실시간 바카라ïve CD8+ T cell subsets through intensity of self-TCR and tonic type I IFN sig실시간 바카라l.
Collectively, 실시간 바카라ïve CD8+ T cells continuously co-opt tonic type I IFN sig실시간 바카라ls with varying sensitivity of self-TCR contacts, which in turn, shapes their unique functio실시간 바카라l properties thatsre not same from one subset to another. The consequence of these effects is to broaden and increase the complexity of 실시간 바카라ïve CD8+ T cell pools withrespect to immune responses beyond their TCR specificity and diversity.
This work was published in 실시간 바카라ture Communications in 2021.