Novel pathogenic mechanism of 스피드 바카라 fungal pathogens
2025-01-22l Hit 268
Crop losses due to 스피드 바카라 diseases account for 30% of the global yearly harvest. Rice blast, which affects rice, causes food losses equivalent to what could feed 60 million people annually, making it one of the most important diseases with significant socio-economic impact.
Resistant varieties and chemical fungicides have been used to control rice blasts. Still, with the increasing frequency of new pathogen and fungicide-resistant strains, there is a growing need for environmentally friendly and sustainable 스피드 바카라 disease control methods.
스피드 바카라 pathogens co-evolve with their host 스피드 바카라s and secrete pathogenic proteins known as effectors to suppress the host 스피드 바카라's immune response. Molecular understanding of effectors is a crucial research area for elucidating the pathogenic mechanisms of pathogens, and thus, many studies are being conducted worldwide.
Among pathogen effectors, nuclear effectors are secreted by the pathogen and move into the host 스피드 바카라's nucleus, where they play a role in regulating the 스피드 바카라's immune response. Our research team first revealed this (Nature Communications 11:5845, 2020). However, the exact mechanism by which nuclear effectors translocate into the host 스피드 바카라's nucleus has not yet been clarified.
A research team led by Professor Emeritus Lee Yong-hwan from the Department of Agricultural Biotechnology at Seoul National University has elucidated the mechanism by which the nuclear effector MoHTR1 of the rice blast fungus translocates into the host 스피드 바카라's nucleus for the first time.
The research team identified the essential nuclear localization sequence (NLS) required for the nuclear effector MoHTR1 to translocate into the host 스피드 바카라's nucleus. Through various molecular biology experiments, they confirmed that this nuclear localization sequence also enables the translocation of cytoplasmic effectors of the rice blast fungus into the nucleus.
The nuclear localization sequence (NLS) of the nuclear effector MoHTR1 was found not only in other rice blast fungus effectors but also in various rice proteins, which were shown to localize in the nucleus within the cell. These findings demonstrate that the NLS of MoHTR1 plays an important role in the nuclear translocation of various proteins.
It was also revealed that for MoHTR1 to translocate into the host 스피드 바카라's nucleus, it must be stabilized through a protein modification process (SUMOylation) and interact with the 스피드 바카라’s importin proteins.
Therefore, the research team utilized various molecular biology and bioinformatics techniques to uncover MoHTR1’s nuclear localization sequence, protein modification process, and interaction with host 스피드 바카라 importins. They ultimately elucidated for the first time how the nuclear localization sequence regulates the pathogen’s pathogenicity and the 스피드 바카라’s immune response.
These research findings will provide a new platform for elucidating not only the pathogenic mechanisms of rice blast fungus but also those of other 스피드 바카라 pathogenic fungi.
This study was supported by the National Research Foundation of Korea and was published on November 11 in Nature Communications (2024 IF=14.7), a prestigious journal in the interdisciplinary research field.
Resistant varieties and chemical fungicides have been used to control rice blasts. Still, with the increasing frequency of new pathogen and fungicide-resistant strains, there is a growing need for environmentally friendly and sustainable 스피드 바카라 disease control methods.
스피드 바카라 pathogens co-evolve with their host 스피드 바카라s and secrete pathogenic proteins known as effectors to suppress the host 스피드 바카라's immune response. Molecular understanding of effectors is a crucial research area for elucidating the pathogenic mechanisms of pathogens, and thus, many studies are being conducted worldwide.
Among pathogen effectors, nuclear effectors are secreted by the pathogen and move into the host 스피드 바카라's nucleus, where they play a role in regulating the 스피드 바카라's immune response. Our research team first revealed this (Nature Communications 11:5845, 2020). However, the exact mechanism by which nuclear effectors translocate into the host 스피드 바카라's nucleus has not yet been clarified.
A research team led by Professor Emeritus Lee Yong-hwan from the Department of Agricultural Biotechnology at Seoul National University has elucidated the mechanism by which the nuclear effector MoHTR1 of the rice blast fungus translocates into the host 스피드 바카라's nucleus for the first time.
The research team identified the essential nuclear localization sequence (NLS) required for the nuclear effector MoHTR1 to translocate into the host 스피드 바카라's nucleus. Through various molecular biology experiments, they confirmed that this nuclear localization sequence also enables the translocation of cytoplasmic effectors of the rice blast fungus into the nucleus.
The nuclear localization sequence (NLS) of the nuclear effector MoHTR1 was found not only in other rice blast fungus effectors but also in various rice proteins, which were shown to localize in the nucleus within the cell. These findings demonstrate that the NLS of MoHTR1 plays an important role in the nuclear translocation of various proteins.
It was also revealed that for MoHTR1 to translocate into the host 스피드 바카라's nucleus, it must be stabilized through a protein modification process (SUMOylation) and interact with the 스피드 바카라’s importin proteins.
Therefore, the research team utilized various molecular biology and bioinformatics techniques to uncover MoHTR1’s nuclear localization sequence, protein modification process, and interaction with host 스피드 바카라 importins. They ultimately elucidated for the first time how the nuclear localization sequence regulates the pathogen’s pathogenicity and the 스피드 바카라’s immune response.
These research findings will provide a new platform for elucidating not only the pathogenic mechanisms of rice blast fungus but also those of other 스피드 바카라 pathogenic fungi.
This study was supported by the National Research Foundation of Korea and was published on November 11 in Nature Communications (2024 IF=14.7), a prestigious journal in the interdisciplinary research field.